KPV
5mg · 99%+ Purity
Description
KPV, a tripeptide fragment of alpha-MSH, demonstrates anti-inflammatory activity through modulation of the innate immune response. It is frequently investigated for its potential role in models of inflammatory bowel disease and skin inflammation.
Disclaimer: The images on this page are for illustrative purposes only. Peptodio is an educational resource and does not sell any products, nor will we ever. We do not recommend or endorse any sellers or vendors. This information is provided for research and educational purposes only.
Research & Science
Evidence-based information about this compound
Chemical Properties
CAS Number
67727-97-3
Molecular Formula
C16H30N4O4
Molecular Weight
342.43 g/mol
Amino Acid Sequence
Lys-Pro-Val
Also known as:
Alpha-MSH (11-13), Tripeptide KPV
KPV is a naturally occurring tripeptide (Lys-Pro-Val) derived from the C-terminal end of α-melanocyte-stimulating hormone (α-MSH). Despite its small size, KPV retains significant anti-inflammatory activity without the pigmentation effects associated with the full α-MSH molecule.
This tripeptide represents one of the smallest bioactive fragments of α-MSH and has been studied for its potent anti-inflammatory effects, particularly in the context of gut inflammation and inflammatory bowel conditions.
KPV's small size and stability make it an attractive compound for research into targeted anti-inflammatory interventions.
KPV exerts anti-inflammatory effects through several mechanisms:
- NF-κB Inhibition: Suppresses nuclear factor kappa-B, a master regulator of inflammation.
- Cytokine Modulation: Reduces production of pro-inflammatory cytokines like TNF-α and IL-6.
- Immune Cell Effects: Modulates activity of macrophages and other immune cells.
- Gut Specificity: Shows particular efficacy in gastrointestinal inflammation models.
- No Melanocortin Binding: Acts independently of classical melanocortin receptors.
KPV has demonstrated significant anti-inflammatory effects:
- Gut Inflammation: Particularly effective in models of inflammatory bowel conditions.
- NF-κB Pathway: Potent inhibitor of this key inflammatory signaling pathway.
- Cytokine Reduction: Decreases levels of multiple pro-inflammatory cytokines.
- Tissue Protection: May protect against inflammatory tissue damage.
The specificity for gut inflammation makes KPV valuable for gastrointestinal research.
This information is provided for educational purposes only and is based on published scientific research. This product is intended for research use only.
