SS-31 (Elamipretide)
5mg · 99%+ Purity
Description
NAD+ 500 is intended for research exploring NAD+'s role as a crucial coenzyme in cellular metabolism and its activation of sirtuin proteins. Studies often investigate NAD+ in the context of age-related decline and cellular energy regulation.
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Research & Science
Evidence-based information about this compound
Chemical Properties
CAS Number
736992-21-5
Molecular Formula
C32H49N9O5
Molecular Weight
639.79 g/mol
Amino Acid Sequence
D-Arg-Dmt-Lys-Phe-NH2
Also known as:
Elamipretide, Bendavia, MTP-131
SS-31 (Elamipretide, also known as Bendavia or MTP-131) is a synthetic tetrapeptide with the sequence D-Arg-Dmt-Lys-Phe-NH2 that specifically targets and concentrates in mitochondria. It belongs to the Szeto-Schiller (SS) peptide family, designed to target the inner mitochondrial membrane.
The peptide selectively binds to cardiolipin, a phospholipid found exclusively in the inner mitochondrial membrane that is essential for optimal mitochondrial function. This targeting mechanism allows SS-31 to directly support mitochondrial health.
SS-31 has been the subject of numerous clinical trials for conditions associated with mitochondrial dysfunction, making it one of the most clinically advanced mitochondria-targeted compounds.
SS-31 supports mitochondrial function through specific mechanisms:
- Cardiolipin Binding: Selectively binds to cardiolipin in the inner mitochondrial membrane.
- Electron Transport: Stabilizes cristae structure and optimizes electron transport chain function.
- ROS Reduction: Decreases reactive oxygen species production at the electron transport chain.
- ATP Production: Supports efficient ATP synthesis by optimizing electron flow.
- Membrane Stability: Helps maintain mitochondrial membrane integrity.
SS-31's effects on mitochondria have been extensively studied:
- ATP Production: Improves ATP synthesis efficiency in various tissue types.
- Oxidative Stress: Reduces mitochondrial ROS production.
- Cristae Structure: Stabilizes the inner membrane folds essential for respiration.
- Age-Related Decline: May counteract age-related mitochondrial dysfunction.
These effects make SS-31 valuable for research into mitochondrial disorders and aging.
Sources:
SS-31 has advanced to human clinical trials:
- Heart Failure: Multiple trials have examined effects in heart failure patients.
- Mitochondrial Myopathies: Studies in primary mitochondrial disease.
- Acute Kidney Injury: Research into renal protection applications.
- Age-Related Conditions: Investigation of effects on age-related functional decline.
Clinical advancement supports SS-31's therapeutic research potential.
Sources:
This information is provided for educational purposes only and is based on published scientific research. This product is intended for research use only.
