MOTS-c
10mg · 99%+ Purity
Description
MOTS-c activates AMPK, mimicking exercise-induced metabolic benefits. Research suggests potential applications in studies exploring improved endurance and metabolic regulation. Purity confirmed via HPLC and mass spectrometry.
Disclaimer: The images on this page are for illustrative purposes only. Peptodio is an educational resource and does not sell any products, nor will we ever. We do not recommend or endorse any sellers or vendors. This information is provided for research and educational purposes only.
Research & Science
Evidence-based information about this compound
Chemical Properties
CAS Number
1627580-64-6
Molecular Formula
C101H152N28O22S2
Molecular Weight
2174.64 g/mol
Amino Acid Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
Also known as:
Mitochondrial ORF of 12S rRNA c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondrial-derived peptide (MDP) consisting of 16 amino acids. It was discovered in 2015 and is encoded within the mitochondrial genome, making it one of several bioactive peptides produced by mitochondria.
MOTS-c has gained significant research interest due to its effects on metabolism, exercise physiology, and aging. It represents a new class of signaling molecules that link mitochondrial function to whole-body metabolic regulation.
The discovery of MOTS-c has opened new avenues of research into how mitochondria communicate with the rest of the body and influence metabolic health.
MOTS-c exerts its effects through several metabolic pathways:
- AMPK Activation: Activates AMP-activated protein kinase, a master regulator of cellular energy homeostasis.
- Glucose Metabolism: Enhances glucose uptake and utilization in skeletal muscle and other tissues.
- Fat Metabolism: Promotes fatty acid oxidation and reduces fat accumulation.
- Mitochondrial Function: May improve mitochondrial function and biogenesis.
- Exercise Mimetic: Research suggests MOTS-c may mimic some metabolic effects of exercise.
MOTS-c has been studied for its wide-ranging metabolic effects:
- Insulin Sensitivity: Research shows MOTS-c improves insulin sensitivity in various models.
- Weight Management: Studies indicate effects on preventing diet-induced obesity.
- Glucose Regulation: Enhances glucose uptake and metabolism in muscle tissue.
- Exercise Benefits: May contribute to metabolic benefits of physical activity.
These metabolic effects position MOTS-c as an important compound for metabolism and aging research.
MOTS-c has emerged as a compound of interest in aging research:
- Healthspan: Studies suggest MOTS-c may improve healthspan markers in aged subjects.
- Physical Function: Research indicates potential benefits for physical function with aging.
- Mitochondrial Health: May support mitochondrial function, which declines with age.
- Endogenous Levels: Circulating MOTS-c levels appear to decline with age.
The connection between mitochondrial function and aging makes MOTS-c a valuable research tool.
Sources:
This information is provided for educational purposes only and is based on published scientific research. This product is intended for research use only.
