Ipamorelin: Research Overview
Ipamorelin is a pentapeptide growth hormone secretagogue that selectively stimulates GH release. It's notable in research for its specificity—it promotes growth hormone release without significantly affecting other pituitary hormones.
Peptide Profile
| Property | Details |
|---|---|
| Type | Growth Hormone Secretagogue |
| Amino Acids | 5 (pentapeptide) |
| Sequence | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ |
| Target | Growth Hormone Secretagogue Receptor (GHSR) |
| Molecular Weight | ~711 g/mol |
| Purity | 99%+ (HPLC verified) |
| Form | Lyophilized powder |
Understanding Growth Hormone Secretagogues
The GH Axis
Growth hormone release is regulated by:
GHS Receptor (GHSR)
The growth hormone secretagogue receptor (GHSR) is activated by:
Ipamorelin's Unique Profile
Selectivity
What distinguishes Ipamorelin in research:
| Parameter | Ipamorelin | Other GHS |
|---|---|---|
| GH release | Yes | Yes |
| Cortisol | Minimal effect | Often increased |
| Prolactin | Minimal effect | Often increased |
| ACTH | Minimal effect | Often increased |
This selectivity makes Ipamorelin valuable for GH-specific research.
Structure
Ipamorelin contains modified amino acids:
These modifications provide:
Research Applications
GH Research
Receptor Studies
Comparative Research
Often studied alongside:
Cell Biology
Reconstitution Protocol
Standard Volumes
| Vial Size | BAC Water | Concentration |
|---|---|---|
| 2mg | 1ml | 2,000mcg/ml |
| 5mg | 2ml | 2,500mcg/ml |
| 5mg | 2.5ml | 2,000mcg/ml |
Procedure
Storage Requirements
Lyophilized
| Storage | Temperature | Duration |
|---|---|---|
| Long-term | -20°C | 2+ years |
| Short-term | 2-8°C | 6-12 months |
Reconstituted
Physical Properties
Appearance
Lyophilized:
Reconstituted:
Stability
Ipamorelin is relatively stable due to:
Research Considerations
Dosing in Research
Research protocols vary, but considerations include:
Common Combinations
Ipamorelin is often researched with:
Controls
Appropriate controls may include:
Quality Indicators
Acceptable
Signs of Degradation
Conclusion
Ipamorelin's selectivity for GH release without significant effects on other hormones makes it a valuable research tool for studying the GH axis. Its well-characterized structure and stability support diverse research applications in endocrinology and receptor biology.
*Ipamorelin is sold for research purposes only and is not intended for human or veterinary use.*
Frequently Asked Questions
What makes Ipamorelin selective?
Ipamorelin selectively stimulates growth hormone release without significantly affecting cortisol, prolactin, or ACTH. This selectivity is due to its specific GHSR binding properties, making it valuable for GH-focused research.
How does Ipamorelin compare to GHRP-6?
Both are growth hormone secretagogues, but Ipamorelin is more selective. GHRP-6 can affect cortisol and prolactin levels, while Ipamorelin has minimal effects on these hormones, making it better for isolated GH research.
Can Ipamorelin be combined with other peptides in research?
Yes, Ipamorelin is often studied alongside GHRH analogs like CJC-1295 or MOD GRF (1-29) to examine synergistic effects on GH release through different receptor mechanisms.
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